(±)-Camphene (Synonyms: DL-Camphene, NSC 4165) |
| カタログ番号GC45277 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79-92-5
Sample solution is provided at 25 µL, 10mM.
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(±)-Camphene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has diverse biological activities, including antiproliferative, pro-apoptotic, hypolipidemic, and insecticidal properties.1,2,3,4,5 It inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (IC50s = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively).2 (±)-Camphene (70 μg/ml) increases caspase-3 activity and induces apoptosis and endoplasmic reticulum stress in B16/F10-Nex2 cells. It lowers plasma levels of total cholesterol, LDL cholesterol, and triglycerides (TGs) in a Triton WR-1339-induced rat model of hyperlipidemia when administered at a dose of 1.5 μg/g.3 Dietary administration of (±)-camphene (0.2%) also inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity.4 It also has larvicidal activity against third instar H. armigera larvae (LC50 = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC50 = 35.39 μg/ml).5 Formulations containing (±)-camphene have been used as perfume and food additives.
References
1. Elzinga, S., Fischedick, J., Podkolinski, R., et al. Cannabinoids and terpenes as chemotaxonomic markers in Cannabis. Nat. Prod. Chem. Res. 3(4), 181 (2015).
2. Girola, N., Figueiredo, C.R., Farias, C.F., et al. Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo. Biochem. Biophys. Res. Commun. 467(4), 928-934 (2015).
3. Vallianou, I., Peroulis, N., Pantazis, P., et al. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PLoS One 6(11), e20516 (2011).
4. Kim, S., Choi, Y., Choi, S., et al. Dietary camphene attenuates hepatic steatosis and insulin resistance in mice. Obesity (Silver Spring) 22(2), 408-417 (2014).
5. Benelli, G., Govindarajan, M., Rajeswary, M., et al. Insecticidal activity of camphene, zerumbone and α-humulene from Cheilocostus speciosus rhizome essential oil against the Old-World bollworm, Helicoverpa armigera. Ecotoxicol. Environ. Saf. 148, 781-786 (2018).
| Cas No. | 79-92-5 | SDF | |
| 同義語 | DL-Camphene, NSC 4165 | ||
| Canonical SMILES | C=C1C2CCC(C2)C1(C)C | ||
| Formula | C10H16 | M.Wt | 136.2 |
| 溶解度 | Chloroform: Soluble,Ethanol: slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.3421 mL | 36.7107 mL | 73.4214 mL |
| 5 mM | 1.4684 mL | 7.3421 mL | 14.6843 mL |
| 10 mM | 0.7342 mL | 3.6711 mL | 7.3421 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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