Myosmine |
| カタログ番号GC14588 |
ナッツおよびナッツ製品に含まれる特定のタバコ アルカロイドであるミオスミンは、a4b2 ニコチン性アセチルコリン作動性受容体 (nAChR) に対する親和性が低く、Ki は 3300 nM です。
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Cas No.: 532-12-7
Sample solution is provided at 25 µL, 10mM.
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Myosmine is a minor tobacco alkaloid that is structurally related to nicotine [1][3][4].
Myosmine is a specific tobacco alkaloid. It is found in a variety of other plants such as maize, rice, wheat flour, millet, potato, and milk and also cocoa, popcorn, tomato, carrot, pineapple, kiwi, and apples. Myosmine is easily nitrosated, yielding 4-hy-droxy-1-(3-pyridyl)-1-butanone (HPB) and a DNA adduct identical to the esophageal tobacco carcinogen N-nitrosonornicotine [2][4].
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. Nicotine is the addictive active ingredient in tobacco smoke that acts as an agonist at neuronal nicotinic acetylcholine receptors with Ki values of 480.69 and 11.13 nM for α3β4 and α4β2 subtypes, respectively [2]. Myosmine weakly binds to a4β2 nACh receptors with Ki value of 3.3 μM [3].
In rats treated with combinations of myosmine and NaNO2, no evidence showed the production of HPB-releasing Hb and DNA adducts, suggesting that exposure to dietary myosmine couldn’t lead to HPB-releasing DNA or Hb adducts in humans [5].
References:
[1]. Tyroller S, Zwickenpflug W, Richter E. New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. J Agric Food Chem. 2002 Aug 14;50(17):4909-15.
[2]. Zaveri N, Jiang F, Olsen C, et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem. 2010 Nov 25;53(22):8187-91.
[3]. Ferretti G1, Dukat M, Giannella M, et al. Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5.
[4]. Zwickenpflug W, Tyroller S, Richter E. Metabolism of myosmine in Wistar rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.
[5]. Hecht SS, Han S, Kenney PM, et al. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chem Res Toxicol. 2007 Mar;20(3):543-9.
| Cas No. | 532-12-7 | SDF | |
| Chemical Name | 3-(3,4-dihydro-2H-pyrrol-5-yl)-pyridine | ||
| Canonical SMILES | C1(C2=NCCC2)=CC=CN=C1 | ||
| Formula | C9H10N2 | M.Wt | 146.2 |
| 溶解度 | ≥ 8.5mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.8399 mL | 34.1997 mL | 68.3995 mL |
| 5 mM | 1.368 mL | 6.8399 mL | 13.6799 mL |
| 10 mM | 0.684 mL | 3.42 mL | 6.8399 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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