NL-1 |
| カタログ番号GC39411 |
NL-1 は、抗白血病効果を持つ mitoNEET 阻害剤です。 NL-1 は、それぞれ 47.35 μM および 56.26 μM の IC50 で REH および REH/Ara-C 細胞の増殖を阻害します。白血病細胞における NL-1 を介した死には、オートファジー経路の活性化が必要です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188532-26-5
Sample solution is provided at 25 µL, 10mM.
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NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 µM and 56.26 µM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway[1].
[1]. Geldenhuys WJ, et al. The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia. J Pharmacol Exp Ther. 2019 Jul;370(1):25-34.
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