PEG2000-DSPE (Synonyms: PEG(2000)-1,2-DSPE, PEG2000-DSPE, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-PE, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine) |
カタログ番号GC64192
One-Click Copy Product Info
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PEG2000-DSPE は、安定化核酸脂質粒子脂質粒子 (SNALP) の調製に使用できます。 SNALPs は、記述された最も初期で最も機能的な siRNA-ABC ナノ粒子のいくつかを表しています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 892144-24-0
Sample solution is provided at 25 µL, 10mM.
PEG2000-DSPE is a PEG polymer containing DSPE and amine end groups that exhibits micelle-like properties [1]. PEG2000-DSPE has been widely used in the preparation of polymer micelles and liposomes to encapsulate doxorubicin, which can prolong the circulation time in the body and thereby increase the tumor uptake rate[2]. The introduction of PEG2000-DSPE will enhance the lateral repulsive force of the lipid bilayer surface through extensive hydration around the head group, not only affecting the particle size, but also influencing the lamellar structure of the vesicles [3]. PEG2000-DSPE has been widely used to modify the surface of nanoparticles or proteins, resisting the degradation by blood proteins and improving the pharmacokinetic behavior of nanocrystals[4].
References:
[1] Remsberg C M, Zhao Y, Takemoto J K, et al. Pharmacokinetic evaluation of a DSPE-PEG2000 micellar formulation of ridaforolimus in rat[J]. Pharmaceutics, 2012, 5(1): 81-93.
[2] Takayama R, Inoue Y, Murata I, et al. Characterization of nanoparticles using DSPE-PEG2000 and soluplus[J]. Colloids and Interfaces, 2020, 4(3): 28.
[3] Sriwongsitanont S, Ueno M. Effect of a PEG lipid (DSPE-PEG2000) and freeze-thawing process on phospholipid vesicle size and lamellarity[J]. Colloid and Polymer Science, 2004, 282(7): 753-760.
[4] Wang D, Wang Y, Zhao G, et al. Improving systemic circulation of paclitaxel nanocrystals by surface hybridization of DSPE-PEG2000[J]. Colloids and Surfaces B: Biointerfaces, 2019, 182: 110337.
| Cas No. | 892144-24-0 | SDF | |
| 同義語 | PEG(2000)-1,2-DSPE, PEG2000-DSPE, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-PE, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine, Polyethylene Glycol-2000-1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine | ||
| Formula | (C2H4O)nC42H82NO10P | M.Wt | |
| 溶解度 | DMSO : 12.5 mg/mL (4.45 mM; ultrasonic and warming and heat to 60°C) | Storage | 4°C, away from moisture and light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)