POB (Synonyms: N-(4′-Pyridoxyl)-L-Ornithine(BOC)-Ome) |
カタログ番号GB40328
One-Click Copy Product Info
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POB（946135-39-3）は、ポリアミン合成に関与する主要な酵素であり、がん治療の潜在的な標的であるODCのプロドラッグ阻害剤である。細胞内では、POBはピリドキサルキナーゼによってリン酸化され、メチルエステルが加水分解されます。この活性化した阻害剤はおそらくapo-ODCに結合し、大幅にODC活性を低下させて細胞増殖を抑制します。 POBはLN229（IC50 = 50μM）、Jurkat、COS7、SW2および高・低グレードの多形性膠芽腫など多種多様な腫瘍細胞株の増殖を抑制することができました。DFMOよりも強力です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 946135-39-3
Sample solution is provided at 25 µL, 10mM.
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POB (946135-39-3) is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
| Cas No. | 946135-39-3 | SDF | |
| 同義語 | N-(4′-Pyridoxyl)-L-Ornithine(BOC)-Ome | ||
| Formula | C19H31N3O6 | M.Wt | 397.47 |
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5159 mL | 12.5796 mL | 25.1591 mL |
| 5 mM | 503.2 μL | 2.5159 mL | 5.0318 mL |
| 10 mM | 251.6 μL | 1.258 mL | 2.5159 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)