PVHD121 |
カタログ番号GB40335
One-Click Copy Product Info
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PVHD121は、有糸分裂中にセントロソームでの微小管形成を選択的に妨害する抗ミトーシス剤であり、強力な抗増殖活性を持つことが示されています。A549（肺）、NCI-H460（肺）、HCT116（大腸）、MCF7（乳房）、PC3（前立腺）およびHeLa（子宮頸部）細胞など、さまざまな腫瘍由来細胞株に対してIC50値が0.1〜0.3μMの範囲で作用します。有糸分裂の分子生物学を研究するための潜在的なツールです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 187336-16-9
Sample solution is provided at 25 µL, 10mM.
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PVHD121 is a potent mitotic inhibitor,an antimitotic agent that selectively disturbs microtubule formation at centrosomes during mitosis. PVHD121 was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 μM. Potential tool for studying the molecular biology of mitosis.
| Cas No. | 187336-16-9 | SDF | |
| Formula | C17H16N2O2 | M.Wt | 280.32 |
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5674 mL | 17.8368 mL | 35.6735 mL |
| 5 mM | 713.5 μL | 3.5674 mL | 7.1347 mL |
| 10 mM | 356.7 μL | 1.7837 mL | 3.5674 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)