SFI003 |
カタログ番号GC73188
One-Click Copy Product Info
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SFI003は、srsf3 / dhcr24 / ros軸を介してcrc細胞のアポトーシスを促進するsrsf3阻害剤であり、in vitroおよびin vivoの両方で強力な抗腫瘍効果を示す。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361332-90-1
Sample solution is provided at 25 µL, 10mM.
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SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo.
SFI003 (0-50 μM, 0-72 h) inhibits the proliferation of HCT116 and SW480 cells in a dose- and time-dependent manner with IC50values of 8.78 µM and 48.67 µM, respectively[1].SFI003 (0-50 μM, 24-72 h) induces apoptosis in HCT-116 and SW480 cells[1].SFI003 (0-50 μM, 24-72 h) induces ROS generation in both HCT-116 and SW480 cells in a dose-dependent manner[1].
SFI003 (p.o., 100, 200 mg/kg; for 2 consecutive weeks) dose-dependently inhibits the growth of HCT-116 and SW480 xenografted SCID mice in vivo[1].
References:
[1]. Zhang Y, et al. A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. Cell Death Discov. 2022 May 2;8(1):238.
| Cas No. | 2361332-90-1 | SDF | |
| Formula | C19H17N5OS | M.Wt | 363.44 |
| 溶解度 | DMSO : 125 mg/mL (343.94 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7515 mL | 13.7574 mL | 27.5149 mL |
| 5 mM | 550.3 μL | 2.7515 mL | 5.503 mL |
| 10 mM | 275.1 μL | 1.3757 mL | 2.7515 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)