Stigmasterol (Synonyms: NSC 8095) |
| カタログ番号GN10359 |
Stigmasterol is a naturally available sterol. stigmasterol has significant anti-arthritis and anti-inflammatory effects.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83-48-7
Sample solution is provided at 25 µL, 10mM.
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Stigmasterol is a naturally available sterol. stigmasterol has significant anti-arthritis and anti-inflammatory effects[1-3].
Stigmasterol(0-100μM;14 h) inhibited glutamate-induced neuronal cell death in the HT-22 cells[4].Stigmasterol(0-20μM;4 h) alleviated Aβ42 oligomers induced inflammatory response in BV2 cells[5].
Stigmasterol(400 mg/kg/d; i. g; 10 days) treatment attenuates DSS-induced colitis in mice[6].Stigmasterol(100 mg/kg;i.p;21-27days) inhibited inflammation and oxidative stress in a mouse model of asthma by NK1-R[7].In the hippocampus of APP/PS1 mice, stigmasterol suppressed the microglia activation[8], and stigmasterol also decreased the TNF-α levels in the cortex of Swiss albino mice[9].
References:
[1]. Antwi AO, Obiri DD, et,al. Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents. Biomed Res Int. 2018 Jul 24;2018:3984068. doi: 10.1155/2018/3984068. PMID: 30140696; PMCID: PMC6081592.
[2]. Gabay O, Sanchez C, et,al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16. doi: 10.1016/j.joca.2009.08.019. Epub 2009 Sep 15. PMID: 19786147.
[3]. Chen WP, Yu C, et,al. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 2012;59(4):537-41. Epub 2012 Oct 16. PMID: 23074702.
[4]. Mongkolpobsin K, Sillapachaiyaporn C, et,al. Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells. Phytomedicine. 2023 May;113:154728. doi: 10.1016/j.phymed.2023.154728. Epub 2023 Feb 24. PMID: 36898255.
[5]. Jie F, Yang X, et,al. Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomed Pharmacother. 2022 Sep;153:113317. doi: 10.1016/j.biopha.2022.113317. Epub 2022 Jun 27. PMID: 35772378.
[6]. Wen S, He L, et,al. Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis. Front Immunol. 2021 Oct 6;12:741934. doi: 10.3389/fimmu.2021.741934. PMID: 34691046; PMCID: PMC8526899.
[7]. Zhang J, Zhang C, et,al. Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. Pharm Biol. 2023 Dec;61(1):449-458. doi: 10.1080/13880209.2023.2173252. PMID: 36788676; PMCID: PMC9930798.
[8]. Koivisto H, Grimm MO, et,al. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. J Nutr Biochem. 2014 Feb;25(2):157-69. doi: 10.1016/j.jnutbio.2013.09.015. Epub 2013 Nov 6. PMID: 24445040.
[9]. Yadav M, Parle M, et,al. Protective effects of stigmasterol against ketamine-induced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice. Pharmacol Rep. 2018 Jun;70(3):591-599. doi: 10.1016/j.pharep.2018.01.001. Epub 2018 Jan 11. PMID: 29679883.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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