USP7-IN-4 (Synonyms: USP7-IN-2, USP7 inhibitor ALM4, AD-04) |
カタログ番号GC28218
One-Click Copy Product Info
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USP7-IN-4 (USP7 inhibitor ALM4) is a non-competitive, potent, and selective inhibitor of USP7 (ubiquitin-specific protease 7).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2196243-57-7
Sample solution is provided at 25 µL, 10mM.
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USP7-IN-4(USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .
| Cas No. | 2196243-57-7 | SDF | |
| 同義語 | USP7-IN-2, USP7 inhibitor ALM4, AD-04 | ||
| Formula | C29H34N6O3 | M.Wt | 514.62 |
| 溶解度 | DMSO: 160 mg/mL (310.91 mM) | Storage | Store at low temperature |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9432 mL | 9.7159 mL | 19.4318 mL |
| 5 mM | 388.6 μL | 1.9432 mL | 3.8864 mL |
| 10 mM | 194.3 μL | 971.6 μL | 1.9432 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)