(+)-Valencene (Synonyms: NSC 148969) |
カタログ番号GC40264
One-Click Copy Product Info
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(+)-バレンセンは、Cに見つかったセスキテルペンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4630-07-3
Sample solution is provided at 25 µL, 10mM.
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(+)-Valencene is a sesquiterpene that has been found in C. sativa and is an aromatic component of orange essence oil.[1],[2] (+)-Valencene (50 µM) induces heme oxgenase-1 (HO-1) expression in macrophages and inhibits the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO), and the release of high-mobility group box-1 (HMGB1) in RAW 264.7 cells stimulated with LPS.[3] It also increases the survival rate in a mouse model of sepsis induced by cecal ligation and puncture. (+)-Valencene has been used in the synthesis of nootkatone.[4]
Referece:
[1]. Naz, S., Hanif, M.A., Bhatti, H.N., et al. Impact of supercritical fluid extraction and traditional distillation on the isolation of aromatic compounds from Cannabis indica and Cannabis sativa. J. Essent. Oil Bearing Plants 20(1), 175-184 (2017).
[2]. Högnadóttir , A., and Rouseff, R.L. Identification of aroma active compounds in orange essence oil using gas chromatography-olfactometry and gas chromatography-mass spectrometry. J. Chromatogr. A. 998(1-2), 201-211 (2003).
[3]. Tsoyi, K., Jang, H.J., Lee, Y.S., et al. (+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction. J. Ethnopharmacol. 137(3), 1311-1317 (2011).
[4]. Kolwek, J., Behrens, C., Linke, D., et al. Cell-free one-pot conversion of (+)-valencene to (+)-nootkatone by a unique dye-decolorizing peroxidase combined with a laccase from Funalia trogii. J. Ind. Microbiol. Biotechnol. 45(2), 89-101 (2018).
| Cas No. | 4630-07-3 | SDF | |
| 同義語 | NSC 148969 | ||
| Chemical Name | (1R,7R,8aS)-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-naphthalene | ||
| Canonical SMILES | CC([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)=C | ||
| Formula | C15H24 | M.Wt | 204.4 |
| 溶解度 | DMSO : 50 mg/mL (244.68 mM; Need ultrasonic) | Storage | Store at 4°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.8924 mL | 24.4618 mL | 48.9237 mL |
| 5 mM | 978.5 μL | 4.8924 mL | 9.7847 mL |
| 10 mM | 489.2 μL | 2.4462 mL | 4.8924 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >70.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)