ZY39 |
カタログ番号GC78995
One-Click Copy Product Info
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ZY39 is a Sa ClpP agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2999673-51-5
Sample solution is provided at 25 µL, 10mM.
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In Vivo, ZY39 (0.5-25 mg/kg; i.p.; single dose) demonstrates superior therapeutic efficacy against S. aureus USA300 infection in zebrafish compared to (R)-ZG197 or vancomycin, respectively[1]. ZY39 (25-50 mg/kg; i.p.; single dose) achieves 89-100% survival and reduces bacterial loads by 2-4 log CFU/g tissue in mice with S. aureus USA300-induced peritonitis[1].
In Vitro, ZY39 potently activates SaClpP-mediated α-casein hydrolysis in vitro with an EC50 of 1.1 μM, and exhibits agonistic activity during the hydrolysis of fluorescein isothiocyanate-casein (FITC-casein) by S. aureus ClpP protease (SaClpP), with an EC50 of 0.33 μM[1]. ZY39 activates the hydrolysis of α-casein by HsClpP in vitro with an EC50 of 3.6 μM, but exhibits extremely low activity against gut microbial ClpP (EcClpP, LaClpP)[1]. ZY39 potently inhibits the growth of both drug-sensitive and multidrug-resistant S. aureus strains in vitro. Its activity depends on functional SaClpP, with MIC values ranging from 0.031 to 0.13 μg/mL[1].
References:
[1]. Zhang T, et al. Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection. J Med Chem. 2025 Jan 23;68(2):1810-1823.
| Cas No. | 2999673-51-5 | SDF | |
| Formula | C28H35F3N4O4 | M.Wt | 548.6 |
| 溶解度 | DMSO: 100 mg/mL (182.28 mM; Need ultrasonic) | Storage | Store at 4°C, protect from light, stored under nitrogen |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8228 mL | 9.1141 mL | 18.2282 mL |
| 5 mM | 364.6 μL | 1.8228 mL | 3.6456 mL |
| 10 mM | 182.3 μL | 911.4 μL | 1.8228 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)