>>Lipids>> Hydroxy/Hydroperoxy/Epoxy/Oxo Eicosanoids>>(±)8,9-DiHET-d11

(±)8,9-DiHET-d11 (Synonyms: (±)8,9DiHETrEd11)

Catalog No.GC46265 Copy One-Click Copy Product Info

A neuropeptide with diverse biological activities

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(±)8,9-DiHET-d11 Chemical Structure

Cas No.: N/A

Size 가격 재고 수량
25 μg
US$280.00
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50 μg
US$528.00
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100 μg
US$996.00
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250 μg
US$2,213.00
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고객 리뷰

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of (±)8,9-DiHET-d11

(±)8,9-DiHET-d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8,9-DiHET by GC- or LC-mass spectrometry. Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.2

1.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982) 2.Zhang, J.Y., Prakash, C., Yamashita, K., et al.Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenaseBiochem. Biophys. Res. Commun.183(1)138-143(1992)

Chemical Properties of (±)8,9-DiHET-d11

Cas No. N/A SDF
Synonyms (±)8,9DiHETrEd11
Canonical SMILES O[C@@H](C/C=C\CCCC(O)=O)[C@H](O)C/C=C\C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Formula C20H23D11O4 M.Wt 349.6
Solubility DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg//ml,PBS (pH 7.2): 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)8,9-DiHET-d11

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8604 mL 14.3021 mL 28.6041 mL
5 mM 572.1 μL 2.8604 mL 5.7208 mL
10 mM 286 μL 1.4302 mL 2.8604 mL
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In vivo Formulation Calculator (Clear solution) of (±)8,9-DiHET-d11

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for (±)8,9-DiHET-d11

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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