Immunology/Inflammation
The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.
Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases [1]. TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN [2].
BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton’s tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5].
Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase [7]. MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.
Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction [8].
References
[1] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.
[2] Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.
[3] Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.
[4] Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.
[5] Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.
[6] Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.
[7] Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.
[8] Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.
Targets for Immunology/Inflammation
- Apoptosis(456)
- Cyclic GMP-AMP Synthase(2)
- 5-Lipoxygenase(18)
- TLR(98)
- Papain(1)
- PGDS(1)
- PGE synthase(24)
- SIKs(12)
- IκB/IKK(63)
- AP-1(6)
- KEAP1-Nrf2(44)
- NOD1(1)
- NF-κB(250)
- Interleukin Related(170)
- 15-lipoxygenase(2)
- Others(10)
- Aryl Hydrocarbon Receptor(36)
- CD73(16)
- Complement System(58)
- Galectin(33)
- IFNAR(25)
- NO Synthase(77)
- NOD-like Receptor (NLR)(51)
- STING(110)
- Reactive Oxygen Species(465)
- FKBP(12)
- eNOS(5)
- iNOS(29)
- nNOS(20)
- Glutathione(57)
- Adaptive Immunity(222)
- Allergy(162)
- Arthritis(34)
- Autoimmunity(190)
- Gastric Disease(101)
- Immunosuppressants(39)
- Immunotherapeutics(5)
- Innate Immunity(593)
- Pulmonary Diseases(119)
- Reactive Nitrogen Species(55)
- Specialized Pro-Resolving Mediators(50)
- Reactive Sulfur Species(28)
- BCL6(3)
- CD20(3)
- CD22(0)
- CD28(1)
- PSMA(7)
- FAP(7)
- Nuclear Factor of activated T Cells (NFAT)(1)
- Glycoprotein VI(1)
- Tim3(2)
- Hapten(1)
- Nectin-4(2)
Products for Immunology/Inflammation
- Cat.No. 상품명 정보
-
GC19910
2,2',4,4'-Tetrabromodiphenyl Ether
BDE-47
-
GC19941
DL-Leucic Acid
-
GC50569
NLRP3-IN-2
glyburide 합성의 중간 기질인 NLRP3-IN-2는 심근세포에서 NLRP3 인플라마좀 형성을 억제하고 포도당 대사에 영향을 미치지 않으면서 마우스에서 심근 허혈/재관류 후 경색 크기를 제한합니다.
-
GC45194
α-(difluoromethyl)-DL-Arginine
DFMA, RMI 71897
Bacteria synthesize the cellular growth factor putrescine through a number of pathways.
-
GC65446
α-Amyrin acetate
α-천연 트리테르페노이드인 아미린 아세테이트는 항염증 활성, 진경제 프로파일 및 이완 효과가 있습니다.
-
GC45200
α-CGRP (rat) (trifluoroacetate salt)
Calcitonin Gene-Related Peptide-1 (rat), α-Calcitonin Gene-Related Peptide (rat), CGRP-1 (rat)
α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. -
GC49838
α-Cortolone
20α-Cortolone, NSC 59872
A metabolite of cortisol -
GC48279
α-D-Glucose-1-phosphate (sodium salt hydrate)
α-D-Glc 1-P
An intermediate in glycogen metabolism -
GC52253
α-Enolase (1-19)-biotin Peptide
Enolase-1 (1-19)-biotin
A biotinylated α-enolase peptide -
GC45206
α-GalCer analog 8
α-Galactosylceramide analog 8
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.
-
GC40262
α-Humulene
αCaryophyllene, (±)-αHumulene
α-Humulene은 Tanacetum vulgare L의 주성분입니다. -
GC45601
α-Linolenic Acid ethyl ester-d5
ALAEE-d5, Ethyl α-Linolenate-d5, Ethyl Linolenate-d5, LAEE-d5, Linolenic Acid ethyl ester-d5
-
GC48292
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2
α-MSH(⋱-멜라닌 세포 자극 호르몬) TFA는 내인성 신경 펩티드이며 항염 및 해열 활성을 갖는 내인성 멜라노코르틴 수용체 4(MC4R) 작용제입니다. -
GC41499
α-Phellandrene
p-Mentha-1,5-diene, (±)-α-Phellandrene
α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities. -
GC63941
α-Solanine
α- 감자의 주요 스테로이드성 글리코알칼로이드 중 하나인 생리활성 성분인 솔라닌이 암세포의 성장을 억제하고 세포자멸사를 유도하는 것으로 관찰되었습니다.
-
GC67618
α-Tocopherol phosphate disodium
alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium
α-유망한 항산화제인 토코페롤 인산염(알파-토코페롤 인산염) 이나트륨은 피부 세포 모델에서 장파 UVA1 유도 세포 사멸을 방지하고 UVA1 유도 활성산소를 제거할 수 있습니다. 821d96072c2d58d8970e76f526b0f6b8α-토코페롤 포스페이트 디소듐은 세포자살 억제에 치료 가능성이 있으며 고포도당/저산소 상태에서 내피 전구 세포의 이동 능력을 증가시키고 혈관 신생을 촉진합니다.821d96072c2d58d8970e76f526b0f6b8 -
GC70953
α7 nAchR-JAK2-STAT3 agonist 1
α7 nAchR-JAK2-STAT3 agonist 1은 강력 한 α 7 nAchR-JAK2-STAT3 효능, μ M 32의 IC50 값을 가지고 있는 질소 산화물 ()이 없다.
-
GC49467
β-Aescin
A triterpenoid saponin with diverse biological activities
-
GC70787
β-Aminoarteether
β-Aminoarteether (SM934 유리알칼리) 는 경구 활성을 가진 아르테미시닌 파생물이다.
-
GC37999
β-Anhydroicaritin
β - Anhydroicaritin은 Boswellia carterii Birdware에서 분리되어 골다공증, 에스트로겐 조절 및 항종양 특성과 같은 중요한 생물학적 및 약리학적 효과가 있습니다.
-
GC45225
β-Apooxytetracycline
β-Apo-Oxytetracycline, β-Apoterramycin
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. -
GC45226
β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. -
GC48920
β-Carboline-1-carboxylic Acid
1-Formic Acid-β-carboline
An alkaloid with diverse biological activities -
GC90496
β-Cortolone
코르티솔의 대사산물
-
GC66870
β-D-Glucan
β-D-글루칸은 천연 비소화성 다당류이며 Dectin-1 및 Toll 유사 수용체와 같은 인식 수용체에 의해 선택적으로 인식될 수 있을 뿐만 아니라 쥐 또는 인간 대식세포에 의해 쉽게 내재화될 수 있는 높은 생체 적합성입니다. 821d96072c2d58d8970e76f526b0f6b8목표 배송에 대한 속성입니다. 821d96072c2d58d8970e76f526b0f6b8β-d-글루칸은 프로바이오틱스의 장용 전달 수단입니다.821d96072c2d58d8970e76f526b0f6b8
-
GC48998
β-Defensin-1 (human) (trifluoroacetate salt)
hBD-1
An antimicrobial peptide -
GC48298
β-Defensin-2 (human) (trifluoroacetate salt)
hBD-2
An antimicrobial peptide -
GC45230
β-Defensin-3 (human) (trifluoroacetate salt)
hBD-3
β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. -
GC45231
β-Defensin-4 (human) (trifluoroacetate salt)
hBD-4 (human)
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. -
GC41623
β-Elemonic Acid
Elemadienonic Acid, 3-Oxotirucallenoic Acid, 3-oxo Tirucallic Acid
β-엘레몬산은 보스웰리아 파피리페라에서 분리된 트리테르펜입니다. -
GC49769
β-Glucogallin
1-O-Galloyl-β-D-glucose
A plant metabolite and an aldose reductase 2 inhibitor -
GC64619
β-Ionone
β-Ionone은 위 선암 SGC7901 세포에서 세포 사멸 유도에 효과적입니다. 항암 활성.
-
GC41502
β-Myrcene
NSC 406264
β-방향족 휘발성 화합물인 Myrcene(β-β-Myrcene)은 TNFα 유도 NF-κB 활성을 억제합니다. -
GC72061
β-Phellandrene
β-Phellandrene 바위뼈에서 얻었습니다.
-
GC45604
β-Rubromycin
β-루브로마이신은 인간 면역결핍 바이러스-1(HIV-1) RNA-유도 DNA 폴리머(역전사효소)의 강력하고 선택적인 억제제입니다.
-
GC52400
γ-Glu-Ala (trifluoroacetate salt)
γ-Glutamylalanine, γ-L-Glutamyl-L-alanine
A dipeptide -
GC48312
γ-Glu-Cys (ammonium salt)
γ-Glutamylcysteine
An intermediate in GSH synthesis -
GC45238
δ14-Triamcinolone acetonide
14,15-dehydro Triamcinolone acetonide, Triamcinolone acetonide Impurity B
δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. -
GC40635
δ2-Avermectin B1a
δ2-Avermectin B1a is a degradation product formed by the reversible base-catalyzed isomerization of ivermectin B1a.
-
GC40307
δ2-cis-Hexadecenoic Acid
One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems.
-
GC41393
ω-3 Arachidonic Acid methyl ester
ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.
-
GC41262
(±)-α-CMBHC
Vitamin E is a well known antioxidant that exists in eight natural forms: four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ).
-
GC41617
(±)-α-Tocopherol
all-rac-α-Tocopherol, DL-α-Tocopherol
(±)-α-토코페롤은 항산화 효과가 있는 합성 비타민 E입니다. -
GC45713
(±)-α-Tocopherol Acetate
all-rac-α-Tocopherol Acetate, DL-α-Tocopherol Acetate, DL-Vitamin E acetate
(±)-α-토코페롤 아세테이트((±)-비타민 E 아세테이트)는 비타민 E의 경구 활성 합성 형태입니다. -
GC46313
(±)-α-Tocopherol Acetate-d3
all-rac-α-Tocopherol Acetate-d3, DL-α-Tocopherol Acetate-d3, DL-Vitamin E Acetate-d3
A neuropeptide with diverse biological activities -
GC67191
(±)-α-Tocopherol nicotinate
(±)-α-토코페롤 니코티네이트, 비타민 E - 니코티네이트는 세포막에서 지질 과산화를 방지하는 경구 활성 지용성 항산화제입니다. 821d96072c2d58d8970e76f526b0f6b8(±)-α-토코페롤 니코티네이트는 혈액에서 α로 가수분해됩니다. 821d96072c2d58d8970e76f526b0f6b8- 토코페롤 및 니아신 관련 혈관 질환 연구에 사용될 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
-
GC52010
(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid
αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE
An oxylipin gut microbiota metabolite -
GC52013
(±)-10-hydroxy-12(Z)-Octadecenoic Acid
10-hydroxy-cis-12-Octadecenoic Acid
An oxylipin and metabolite of linoleic acid -
GC52421
(±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5
10-hydroxy-cis-12-Octadecenoic Acid-d5
An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid -
GC45277
(±)-Camphene
DL-Camphene, NSC 4165
-
GC40112
(±)-Climbazole-d4
(±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS.
-
GC91298
(±)-Linalool-d3
(±)-리날룰 양적 분석을 위한 내부 표준제
-
GC50708
(±)-ML 209
An RORγt antagonist
-
GC39271
(±)-Naringenin
SDihydrogenistein, NSC 11855, NSC 34875, Salipurol
(±)-나린제닌은 자연적으로 발생하는 플라보노이드입니다. -
GC90022
(±)-Norepinephrine-d6 (hydrochloride)
노르에피네프린 양적 분석을 위한 내부 표준입니다.
-
GC41212
(±)10(11)-EpDPA
(±)10,11-EDP, (±)10,11-EpDPE, (±)10,11-epoxy DPA, (±)10,11-epoxy Docosapentaenoic Acid
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. -
GC40466
(±)11(12)-EET
(±)11,12-EpETrE
(±)11(12)-EET는 NLRP3 인플라마좀 억제제입니다. -
GC45922
(±)11(12)-EET-d11 methyl ester
(±)11,12-EpETrE-d11 methyl ester
A neuropeptide with diverse biological activities -
GC40467
(±)11-HETE
(±)11-Hydroxyeicosatetraenoic Acid
(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. -
GC40802
(±)12(13)-DiHOME
Isoleukotoxin diol
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
-
GC46256
(±)12(13)-DiHOME-d4
Isoleukotoxin diold4
A neuropeptide with diverse biological activities -
GC41191
(±)13(14)-EpDPA
(±)13,14-EDP, (±)13,14-EpDPE, (±)13,14-epoxy DPA, (±)13,14-epoxy Docosapentaenoic Acid
(±)13(14)-EpDPA(13,14-EpDPE)는 시토크롬 P-450 에폭시게나제와 도코사헥사엔산(DHA)의 반응 생성물입니다. -
GC40355
(±)13-HpODE
13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide
(±)13-HpODE(13-hydroperoxylinoleic acid)는 lipoxygenase에 의한 리놀레산의 산화에 의해 생성되는 과산화수소의 라세미 혼합물입니다. -
GC41288
(±)17(18)-EpETE-Ethanolamide
17,18-EEQ-EA, (±)17,18-EEQ-Ethanolamide, (±)17(18)-EpETE-EA, 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide
(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. -
GC40362
(±)18-HEPE
(±)18-HEPE is produced by non-enzymatic oxidation of EPA.
-
GC41655
(±)19(20)-EDP Ethanolamide
19,20-DHEA epoxide, 19,20-epoxy Docosapentaenoic Acid Ethanolamide, 19,20-EDP-EA, 19,20-EDP epoxide
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). -
GC40270
(±)5(6)-DiHET
(±)5,6-DiHETrE
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
-
GC41203
(±)7(8)-EpDPA
(±)7,8-EDP, (±)7,8-EpDPE, (±)7,8-epoxy DPA, (±)7,8-epoxy Docosapentaenoic Acid
Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. -
GC40440
(±)8(9)-EET
(±)8,9EpETrE
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. -
GC40838
(±)8(9)-EET methyl ester
(±)8,9EpETrE methyl ester
(±)8(9)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450. -
GC46264
(±)8(9)-EET-d11
(±)8,9-EET-d11, (±)8,9-EpETrE-d11
A neuropeptide with diverse biological activities -
GC45921
(±)8(9)-EET-d11 methyl ester
(±)8,9-EpETrE-d11 methyl ester
A neuropeptide with diverse biological activities -
GC40801
(±)9(10)-DiHOME
Leukotoxin diol
(±)9(10)-DiHOME은 9,10-DiHOME의 라세미체입니다. -
GC40540
(±)9(10)-EpOME
Coronaric Acid, (±)9,10EODE, Leukotoxin
(±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. -
GC46000
(•)-Drimenol
NSC 169775
A sesquiterpene alcohol -
GC40809
(+)-β-Citronellol
(R)-Citronellol, (+)-Citronellol, (+)-(R)-Citronellol, (R)-(+)-β-Citronellol
(+)-β-시트로넬롤(D-시트로넬롤)은 제라늄 에센셜 오일에서 발견되는 알코올성 모노테르펜입니다. -
GC49268
(+)-δ-Cadinene
A sesquiterpene with antimicrobial and anticancer activities
-
GC41346
(+)-Cedrol
(+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities.
-
GC45263
(+)-D-threo-PDMP (hydrochloride)
D-PDMP
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. -
GC31691
(+)-DHMEQ
(1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ
(+)-DHMEQ는 항산화 전사 인자 Nrf2의 활성화제입니다. -
GC74247
(+)-Glaucarubinone
(+)-Glaucarubinone 는 강력한 AP-1 활성 단백질-1 억제제로서 EC50 값은 0.13 µM입니다.
-
GC45266
(+)-Macrosphelide A
(+)-Macrosphelide A는 macrolide 항생제입니다.
-
GC40266
(+)-Praeruptorin A
(+)-Praeruptorin A는 Peucedanum praeruptorum(Bai-Hua Qian Hu라고도 함)의 주요 생리 활성 성분입니다.
-
GC18749
(+)-Rugulosin
NSC 160880, NSC 249990, Rugulosin A
(+)-Rugulosin은 Penicillium rugulosum Thom의 결정질 착색 물질입니다. -
GC63969
(+)-Schisandrin B
(+)-Schisandrin B는 Schisandrin B의 거울상 이성질체입니다.
-
GC40264
(+)-Valencene
NSC 148969
(+)-Valencene is a sesquiterpene that has been found in C.
-
GC49502
(-)-β-Sesquiphellandrene
A sesquiterpene with antiviral and anticancer activities
-
GC32705
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin)
Dehydroxymethylepoxyquinomicin
(-)-DHMEQ(Dehydroxymethylepoxyquinomicin)(Dehydroxymethylepoxyquinomicin)는 시스테인 잔기에 공유 결합하는 강력하고 선택적이고 비가역적인 NF-κB 억제제입니다. -
GC14049
(-)-Epigallocatechin gallate (EGCG)
EGCG
(-)-Epigallocatechin gallate (EGCG)은 녹차의 주요 폴리페놀로 세포 증식을 억제하고 조사소를 유도한다. -
GC40218
(-)-Epigallocatechin Gallate-d3/d4
EGCG-d3/d4
(-)-Epigallocatechin gallate-d3/d4 is intended for use as an internal standard for the quantification of (-)-epigallocatechin gallate by GC- or LC-MS. -
GC45248
(-)-FINO2
(-)-FINO2는 강력한 ferroptosis 유도제입니다. (-)-FINO2는 GPX4 활성을 억제합니다. (-)-FINO2는 제1철을 산화시키는 안정한 산화제이며 다양한 pH 수준에서 안정합니다. (-)-FINO2는 광범위한 지질 과산화를 유발합니다.
-
GC46245
(-)-G-Lactone
A bicyclic γ-lactone
-
GC38316
(-)-Limonene
(±)-Dipentene, DL-Limonene, NSC 844, NSC 21446
(-)-리모넨((S)-(-)-리모넨)은 많은 솔잎 오일과 테레빈유에서 발견되는 모노테르펜입니다. -
GC46247
(-)-Mycousnine
Mycousunin
A microbial metabolite with antibacterial and antifungal activities -
GC45251
(-)-Neplanocin A
S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine.
-
GC90533
(-)-Pinoresinol
다양한 생물학적 활동을 가진 리그난
-
GC45272
(-)-Rasfonin
TT-1
(-)-Rasfonin은 곰팡이 2차 대사 산물이며 작은 G 단백질 Ras를 억제합니다. (-)-Rasfonin은 ACHN 세포(신장암 세포주)에서 세포자살, 괴사 및 자가포식을 유도합니다. -
GC40803
(25S)-δ7-Dafachronic Acid
UPF1404
During unfavorable environmental conditions, C. -
GC41697
(Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)
AY-NH2, AYPGKF-NH2, H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2, PAR4-AP, Proteinase-Activated Receptor 4 Activating Peptide
(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). -
GC52442
(D)-PPA 1 (trifluoroacetate salt)
DPPA-1, NYSKPTDRQYHF
An inhibitor of the PD-1-PD-L1 protein-protein interaction