9-cis-β-Carotene |
| Catalog No.GC62819 |
9-cis-β-레티날의 전구체인 카로틴은 베타-카로틴 옥시게나제 1(BCMO1)에 의해 절단되어 9-시스-레티날을 생성합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13312-52-2
Sample solution is provided at 25 µL, 10mM.
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9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus[1].
9-cis-β-Carotene (1 μM; 18 hours) formulates with the Miglyol 810 and the"antioxidant mix" is incubated to eye cups. The eye cups are isolated from the neuro-retina attached to the underlying RPE tissue from RPE65rd12 mouse. It prevents S- and M-cones degeneration and leads to over 2- and 9- fold higher m-opsin and s-opsin positive staining compares to the control group[1].
In a mouse model of retinoid cycle defect, RPE65rd12. Mice with an extract of Dunaliella Bardawil algae rich in 9-cis-β-Carotene (9CBC) rescues retinal function and preserves cone structure by oral administration[1].
[1]. Sher I, et al.Synthetic 9-cis-beta-carotene inhibits photoreceptor degeneration in cultures of eye cups from rpe65rd12 mouse model of retinoid cycle defect.Sci Rep. 2018 Apr 17;8(1):6130.
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