β-Defensin-1 (human) |
| Catalog No.GC45229 |
β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of B. adolescentis, L. acidophilus, B. breve, B. vulgatus, L. fermentum, B. longum, and S. thermophilus in an antimicrobial radial diffusion assay. β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius, and of susceptible M. tuberculosis H37Rv but not of resistant M. tuberculosis RM22 when used at a concentration of 128 µg/ml. It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively). Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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