Ac-VDVAD-AFC (trifluoroacetate salt) (Synonyms: N-Acetyl-Val-Asp-Val-Ala-Asp-AFC, N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-2 Substrate (Fluorogenic)) |
| Catalog No.GC52372 |
A fluorogenic substrate for caspase-2
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2.1,2 Upon enzymatic cleavage by caspase-2, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-2 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively.
1.Moriya, R., Uehara, T., and Nomura, Y.Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cellsFEBS Lett.484(3)253-260(2000) 2.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997)
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