AC1-IN-1 |
| Catalog No.GC65376 |
AC1-IN-1은 IC50이 0.54 μM인 강력하고 선택적인 Adenylyl cyclase type 1(AC1) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2762422-55-7
Sample solution is provided at 25 µL, 10mM.
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AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity[1].
AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line[1].
AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point[1].
[1]. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686.
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