Afegostat (D-Isofagomine) (Synonyms: D-Isofagomine; Isofagomine) |
| Catalog No.GC33728 |
Afegostat(D-Isofagomine)은 소포체(ER)의 acid-β-glucosidase(GCase)에 높은 친화력으로 특이적이고 가역적으로 결합하는 약리학적 샤페론입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 169105-89-9
Sample solution is provided at 25 µL, 10mM.
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Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].
[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.
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