Alyssin (Synonyms: 5-Methylsulfinylpentyl isothiocyanate, 5-Methylsulfinylpentyl ITC) |
Catalog No.GC46835 |
십자화과 야채에서 발견되는 Alyssin은 세포 내 활성 산소 종과 tubulin depolymerization을 증가시켜 HepG2에서 항암 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 646-23-1
Sample solution is provided at 25 µL, 10mM.
Alyssin is an isothiocyanate that has been found in W. japonica and has diverse biological activities, including antibacterial, fungicidal, CYP inhibitory, and antiproliferative properties.1,2,3 It is active against the bacteria B. subtilis, methicillin-sensitive S. aureus, methicillin-resistant S. aureus (MRSA), and E. coli, and the plant pathogenic fungus A. niger.1 Alyssin (0.5-2.5 µM) directly inhibits activity of the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 induced by the polycyclic aromatic hydrocarbons (PAHs) anthracene and dibenzo[a,h]anthracene in MCF-7 breast cancer cells.2 It inhibits proliferation of HCT116 colon cancer cells (IC50 = <4 µM).3 Alyssin also inhibits platelet aggregation induced by ADP or arachidonic acid (IC50s = 168 and 20 µM, respectively).4
1.Masuda, H., Harada, Y., Kishimoto, N., et al.Antimicrobial Activities of IsothiocyanatesAroma Active Compounds in Foods229-250(2001) 2.Skupinska, K., Misiewicz-Krzeminska, I., Lubelska, K., et al.The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cellsToxicol. In Vitro23(5)763-771(2009) 3.Kim, M.J., Kim, S.H., and Lim, S.-J.Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cellsAnticancer Res.30(9)3611-3619(2010) 4.Morimitsu, Y., Hayashi, K., Nakagawa, Y., et al.Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, WasabiMech. Ageing Dev.116(2-3)125-134(2000)
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