AMG PERK 44 |
| Catalog No.GC39156 |
AMG PERK 44는 IC50이 6nM인 경구 활성 및 고도로 선택적인 PERK 억제제입니다. AMG PERK 44는 GCN2(IC50=7300nM) 및 B-Raf(IC50 >1000nM)에 대해 각각 1000배 및 160배 선택성을 가지고 있습니다. AMG PERK 44는 자가포식을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-84-2
Sample solution is provided at 25 µL, 10mM.
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AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively[1][2].
[1]. Smith AL, et al. Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J Med Chem. 2015 Feb 12;58(3):1426-41. [2]. Roest G, et al. The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells. 2018 Nov 30;7(12). pii: E239.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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