Aminooxy-PEG4-alcohol |
Catalog No.GC67147 |
아미노옥시-PEG4-알코올은 항체-약물 접합체(ADC)의 합성에 사용되는 절단 불가능한 4단위 PEG ADC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8아미노옥시-PEG4-알코올은 또한 PROTAC 합성에 사용될 수 있는 PEG 기반 PROTAC 링커입니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 106492-60-8
Sample solution is provided at 25 µL, 10mM.
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.
[2]. Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3.
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