AN2718 |
| Catalog No.GC32324 |
AN2718은 OBORT(옥사보롤 tRNA 트래핑) 메커니즘을 사용하여 단백질 합성을 차단하여 곰팡이 성장을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 174672-06-1
Sample solution is provided at 25 µL, 10mM.
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AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes[1].
[1]. Seiradake, et al. Antifungal activity and mechanism of action of a benzoxaborole, AN2718, which is in development for the treatment of tinea pedis. 48th Annual ICAAC/46th Annual IDSA (2008).
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