APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) |
| Catalog No.GC33702 |
APNEA(N6-[2-(4-아미노페닐)에틸]아데노신)(N6-[2-(4-아미노페닐)에틸]아데노신)는 강력한 비선택적 A3 아데노신 수용체 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
![APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) Chemical Structure](/media/struct/GC3/GC33702.png "APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) Chemical Structure")
Cas No.: 89705-21-5
Sample solution is provided at 25 µL, 10mM.
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APNEA is a potent, non-selective A3 adenosine receptor agonist.
APNEA is a non-selective agonist of the adenosine A3 receptors, at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiates the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at lower doses. APNEA (0.0039-1 mg/kg) also enhances the protective activity of carbamazepine. APNEA at low doses potentiates the protective activity of Carbamazepine most likely through the A subtype of adenosine receptors. At higher doses, APNEA seems to enhance the anticonvulsive effect of other antiepileptics via adenosine A1 receptors[1].
APNEA (2-4 mg/kg) has no significant effect on seizure parameters (seizure severity, seizure duration and afterdischarge duration) in amygdala-kindled rats. N6-[2-(4-Aminophenyl)ethyl]adenosine is combined with antiepileptic drugs administered at doses ineffective in fully kindled rats[1].
[1]. Borowicz KK, et al. N6-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive activity of antiepileptic drugs. Eur J Pharmacol. 1997 May 30;327(2-3):125-133. [2]. Borowicz KK, et al. N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats. Eur Neuropsychopharmacol. 2000 Jul;10(4):237-243.
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