AR-C 141990 hydrochloride |
| Catalog No.GC50226 |
AR-C 141990 염산염은 MCT-1 및 MCT-2에 대해 각각 pKi 값이 7.6, 6.6인 강력한 젖산 수송체(모노카르복실레이트 수송체, MCT) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250019-94-2
Sample solution is provided at 25 µL, 10mM.
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Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.
Påhlman et al (2012) Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 26 22 PMID:23137339 |Thiesen et al (2015) In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 354 166 PMID:25986445
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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