Auxinole |
| Catalog No.GC30028 |
옥시놀은 TIR1/AFB 수용체의 강력한 옥신 길항제로서, TIR1에 결합하여 TIR1-IAA-Aux/IAA 복합체의 형성을 차단하고 옥신 반응성 유전자 발현을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86445-22-9
Sample solution is provided at 25 µL, 10mM.
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Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.
Auxinole is a potent auxin antagonist of TIR1/AFB receptors, and binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and then inhibits auxin-responsive gene expression. In addition, Auxinole competitively inhibits various auxin responses in planta[1]. Auxinole causes reduction in IAA-triggered depolarization in root hair cells. Auxinole (20 µM) also represses the transient increase in [Ca2+]cyt completely, and blocks Ca2+ response[2].
[1]. Hayashi K, et al. Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem Biol. 2012 Mar 16;7(3):590-8. [2]. Dindas J, et al. AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling. Nat Commun. 2018 Mar 21;9(1):1174.
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