(+)-Biotin-ONP (Synonyms: (+)-Biotin 4-nitrophenyl ester) |
| Catalog No.GC64752 |
(+)-Biotin-ONP는 PROTAC 합성에 사용할 수 있는 알킬 사슬 기반 PROTAC 링커입니다.
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Cas No.: 33755-53-2
Sample solution is provided at 25 µL, 10mM.
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(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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