RBN-2397 |
| Catalog No.GC39504 |
RBN-2397은 PARP7(IC50<3nM)의 강력한 종 및 경구 활성 NAD+ 경쟁 억제제입니다. RBN-2397은 PARP7(Kd=0.001μM)에 선택적으로 결합하고 IFN 신호를 복원합니다. RBN-2397은 진행성 또는 전이성 고형 종양 연구에 대한 가능성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2381037-82-5
Sample solution is provided at 25 µL, 10mM.
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RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores interferon (Type I) signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors[1][2].
[1]. RBN-2397-Inhibiting PARP7, a Key monoPARP Cancer Dependency [2]. Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor Targetinga Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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