Deoxyelephantopin |
| Catalog No.GC60129 |
Elephantopus scaber의 천연 생리 활성 세스퀴테르펜 락톤인 데옥시엘레판토핀은 광범위한 암에 대해 유망한 항암 효과를 보여주었습니다. 데옥시엘레판토핀은 NF-κB, MAPK, PI3K/Akt 및 β-카테닌 신호전달을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 29307-03-7
Sample solution is provided at 25 µL, 10mM.
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Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].
Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1].Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].
[1]. Farha Arakkaveettil Kabeer, et al. Molecular Mechanisms of Anticancer Activity of Deoxyelephantopin in Cancer Cells. Integr Med Res. 2017 Jun;6(2):190-206.
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