14S(15R)-EET (Synonyms: 14S,15R-EpETrE) |
| Catalog No.GC46438 |
A cytochrome P450 metabolite of arachidonic acid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 105304-92-5
Sample solution is provided at 25 µL, 10mM.
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14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .1 14S(15R)-EET binds to isolated guinea pig monocytes with a Ki value of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2 It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 4 pM) and denuded porcine subepicardial arterioles (EC50 = 3 pM).3 Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4
1.Daikh, B.E., Lasker, J.M., Raucy, J.L., et al.Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C91J. Pharmacol. Exp. Ther.271(3)1427-1433(1994) 2.Wong, P.Y.-K., Lai, P.-S., and Falck, J.R.Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytesProstaglandins Other Lipid Mediat.62(4)321-333(2000) 3.Zhang, Y., Oltman, C.L., Lu, T., et al.EET homologs potently dilate coronary microvessels and activate BKCa channelsAm. J. Physiol. Heart Circ. Physiol.280(6)H2430-H2440(2001) 4.Fitzpatrick, F.A., Ennis, M.D., Baze, M.E., et al.Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acidsJ. Biol. Chem.261(2)15334-15338(1986)
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