19R(20S)-EpDPA (Synonyms: 19R,20S-epoxy Docosapentaenoic Acid, 19R,20S-epoxy DPA, 19R,20S-EDP, 19R,20S-EpDPE) |
| Catalog No.GC46475 |
A DHA metabolite
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2242542-60-3
Sample solution is provided at 25 µL, 10mM.
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19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2 It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.2 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).3
1.Cinelli, M.A., Yang, J., Scharmen, A., et al.Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acidsJ. Lipid Res.59(11)2237-2252(2018) 2.Lucas, D., Goulitquer, S., Marienhagen, J., et al.Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450J. Lipid Res.51(5)1125-1133(2010) 3.Burke, J.E., and Dennis, E.A.Phospholipase A2 structure/function, mechanism, and signalingJ. Lipid Res.50(Suppl)S237-S242(2009)
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