Alloisolithocholic Acid (Synonyms: AILCA, Isoallolithocholic Acid, NSC 18169) |
| Catalog No.GC46831 |
리토콜산의 유도체인 알로이소리토콜산(3β-Hydroxy-5α-콜란산)은 T 세포 조절제입니다.
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Cas No.: 2276-93-9
Sample solution is provided at 25 µL, 10mM.
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Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.1,2 It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).1 AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.2
1.Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008) 2.Vonk, R.J., Tuchweber, B., MassÉ, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)
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