Galnon (trifluoroacetate salt) (Synonyms: Fmoc-β-Cha-Lys-AMC)

Galnon is a galanin (GAL) receptor agonist (K_D = 2.9 µM in Bowes cells expressing GAL₁ receptors).¹ It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC₅₀ = 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole . It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.² Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.³

1.Saar, K., Mazarati, A.M., Mahlapuu, R., et al.Anticonvulsant activity of a nonpeptide galanin receptor agonistProc. Natl. Acad. Sci. USA99(10)7136-7141(2002) 2.Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al.The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortexAddict. Biol.20(4)701-713(2015) 3.Abramov, U., FlorÉn, A., Echevarria, D.J., et al.Regulation of feeding by galnonNeuropeptides38(1)55-61(2004)