Glycochenodeoxycholic Acid-d4 (Synonyms: GCDCA-d4) |
Catalog No.GC47408 |
글리코케노데옥시콜산-d4(케노데옥시콜릴글리신-d4)는 글리코케노데옥시콜산으로 표지된 중수소입니다. 글리코케노데옥시콜산(케노데옥시콜릴글리신)은 케노데옥시콜레이트와 글리신으로부터 간에서 형성되는 담즙산입니다. 흡수를 위해 지방을 가용화하는 세제 역할을 하고 자체적으로 흡수됩니다. Glycochenodeoxycholic acid (Chenodeoxycholylglycine)는 간세포 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1201918-16-2
Sample solution is provided at 25 µL, 10mM.
An internal standard for the quantification of glycochenodeoxycholic acid by GC- or LC-MS. GCDCA is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid .1 It reduces formation of cholic acid in primary human hepatocytes when used at a concentration of 100 µM.2 GCDCA (50, 75, and 100 µM) reduces the number LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes.1 GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine .3 Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.4
1.Lan, W., Chen, Z., Chen, Y., et al.Glycochenodeoxycholic acid impairs transcription factor E3-dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cellsToxicol. Lett.33111-21(2020) 2.Ellis, E., Axelson, M., Abrahamsson, A., et al.Feedback regulation of bile acid synthesis in primary human hepatocytes: Evidence that CDCA is the strongest inhibitorHepatology38(4)930-938(2003) 3.Gonzalez, B., Fisher, C., and Rosser, B.G.Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activityMol. Cell. Biochem.207(1-2)19-27(2000) 4.Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)
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