Hydroflumethiazide-13C-d2 (Synonyms: Methforylthiazidine-13C,d2; Rontyl-13C,d2) |
| Catalog No.GC47441 |
An internal standard for the quantification of hydroflumethiazide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1189877-11-9
Sample solution is provided at 25 µL, 10mM.
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Hydroflumethiazide-13C-d2 is intended for use as an internal standard for the quantification of hydroflumethiazide by GC- or LC-MS. Hydroflumethiazide is a thiazide diuretic and an inhibitor of carbonic anhydrase (CA).1 It is selective for CAII, CAVB, CAVII, CAIX, CAXII, and CAXIV (Kis = 0.24-0.31 µM) over CAI, CAIV, and CAVI (Kis = 2.8-8.3 µM), as well as CAIII, CAVA, and CAXIII (Kis = >10 µM). Formulations containing hydroflumethiazide have been used in the treatment of hypertension.
1.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008)
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