Pyridostatin (trifluoroacetate salt) (Synonyms: RR82 TFA) |
| Catalog No.GC48016 |
피리도스타틴(RR82) TFA는 G-quadruplex DNA 안정화제입니다(Kd=490nM). 피리도스타틴(트리플루오로아세테이트 염)은 복제 및 전사 의존성 DNA 손상을 유도하여 인간 암세포의 성장 정지를 촉진합니다. Pyridostatin(trifluoroacetate salt)은 proto-oncogene Src를 표적으로 합니다. 피리도스타틴(트리플루오로아세테이트 염)은 인간 유방암 세포에서 SRC 단백질 수준과 SRC 의존성 세포 운동성을 감소시켰습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1472611-44-1
Sample solution is provided at 25 µL, 10mM.
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Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.1
1.Rodriguez, R., Miller, K.M., Forment, J.V., et al.Small-molecule-induced DNA damage identifies alternative DNA structures in human genesNat. Chem. Biol.8(3)301-310(2012)
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