Sporothriolide

Sporothriolide is a fungal metabolite that has been found in Sporothrix.¹ It is active against the plant pathogenic fungi U. violacea, M. microspore, and E. repens, and the alga C. fusca, but not the bacteria B. megaterium and E. coli, when used at a concentration of 10 mg/ml. Sporothriolide inhibits mycelial growth of the plant pathogenic fungus R. solani (EC₅₀ = 3.04 µg/ml) and protects against R. solani-induced rice sheath blight on rice plants when used at a concentration of 200 µg/ml.² It also prevents necrosis induced by the plant pathogenic fungus B. cinerea in pepper seedlings at 500 ppm.¹ Sporothriolide (4 mg/ml) prevents germination of L. sativum and M. sativa seedlings.

1.Krohn, K., Ludewig, K., Aust, H.-J., et al.Biologically active metabolites from fungi. 3. sporothriolide, discosiolide, and 4-epi-ethisolide--new furofurandiones from Sporothrix sp., Discosia sp., and Pezicula lividaJ. Antibiot. (Tokyo)47(1)113-118(1994) 2.Cao, L.-L., Zhang, Y.-Y., Liu, Y.-J., et al.Anti-phytopathogenic activity of sporothriolide, a metabolite from endophyte Nodulisporium sp. A21 in Ginkgo bilobaPestic. Biochem. Physiol.1297-13(2016)