4'-Acetyl Chrysomycin A |
| Catalog No.GC48437 |
A bacterial metabolite with antibacterial and anticancer activities
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found in Streptomyces and has antibacterial and anticancer activities.1 It is active against strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant strains of E. faecalis and E. faecium (MICs = 0.5-2 µg/ml for all). 4'-Acetyl chrysomycin A is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 0.085-0.26 and 3.4-16 ng/ml, respectively).
1.Wada, S.-I., Sawa, R., Iwanami, F., et al.Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and BJ. Antibiot. (Tokyo)70(11)1078-1082(2017)
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