Clobetasol Propionate-d5 (Synonyms: CCI-4725-d5, CGP 9555-d5, Clobetasol 17-propionate-d5)

Clobetasol propionate-d₅ is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid.¹ It binds to glucocorticoid receptors in a cell-free assay (IC₅₀ = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.^1,2 Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.¹ Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.

1.Ueno, H., Maruyama, A., Miyake, M., et al.Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional groupJ. Med. Chem.34(8)2468-2473(1991) 2.Ponec, M., de Haas, C., Bachra, B.N., et al.Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblastsArch. Dermatol. Res.259(12)117-123(1977)