Avrainvillamide (Synonyms: CJ-17,665) |
Catalog No.GC48511 |
Avrainvillamide((+)-Avrainvillamide)는 항증식 효과가 있는 자연 발생 알칼로이드로, 다양한 인간 종양에서 과발현되는 제안된 발암성 단백질인 핵 샤페론 뉴클레오포스민에 결합합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 269741-97-1
Sample solution is provided at 25 µL, 10mM.
Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found in A. ochraceus.1,2 It is active against S. aureus, S. pyogenes, and E. faecalis (MICs = 12.5, 12.5, and 25 µg/ml, respectively).2 Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI50 values of 0.24, 0.62, 0.21, and 0.41 µM, respectively.1
1.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 2.Sugie, Y., Hirai, H., Inagaki, T., et al.A new antibiotic CJ-17,665 from Aspergillus ochraceusJ. Antibiot.54(11)911-916(2001)
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