KRP 297 (Synonyms: MK-767) |
| Catalog No.GC48521 |
KRP 297은 잠재적으로 제2형 당뇨병 및 이상지질혈증 치료를 위한 PPARα 및 PPARγ 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 213252-19-8
Sample solution is provided at 25 µL, 10mM.
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KRP 927 is a thiazolidinedione dual agonist of PPARα and PPARγ (EC50s = 149 and 83 nM, respectively, in transactivation assays).1 It decreases hyperglycemia and hyperinsulinemia in ob/ob mice in a dose-dependent manner. KRP 927 (10 or 30 mg/kg) reduces serum total cholesterol and triglyceride levels in hamsters.
1.Doebber, T.W., Kelly, L.J., Zhou, G., et al.MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activitiesBiochem. Biophys. Res. Commun.318(2)323-328(2004)
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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