Isorhoifolin (Synonyms: Apigenin-7-O-rutinoside)

Isorhoifolin is a flavonoid glycoside and an aglycone form of apigenin that has been found in M. longifolia and has diverse biological activities.^1,2,3 It inhibits matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-13 (IC₅₀s = 0.33, 2.45, and 0.22 µM, respectively).¹ Isorhoifolin has antimutagenic properties in the E. coli WP2 tryptophan reverse mutation assay when used at a concentration of 2 µM.² It is active against S. aureus and P. aeruginosa, but not E. coli or C. albicans, in agar diffusion assays when used at a concentration of 140 µg/ml.³

1.Crasci, L., Basile, L., Panico, A., et al.Correlating in vitro target-oriented screening and docking: Inhibition of matrix metalloproteinases activities by flavonoidsPlanta Med.83(11)901-911(2017) 2.Baris, O., Karadayi, M., Yanmis, D., et al.Isolation of 3 flavonoids from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potentials by using the E. coli WP2 test systemJ. Food. Sci.76(9)T212-T217(2011) 3.Abu-Gharbieh, E., and Shehab, N.G.Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compoundsBMC Complement. Altern. Med.17(1)218(2017)