- Cat.No. 상품명 정보
- GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
- GC47450 IL-4 Inhibitor IL-4 억제제(화합물 52)는 1.81 μ의 EC50을 갖는 IL-4 억제제입니다.
- GC49150 Tpl2 Kinase Inhibitor (hydrochloride) A Tpl2 inhibitor
- GC47931 PDE4B Inhibitor A PDE4B inhibitor
- GC18602 p38 MAPK Inhibitor IV p38 MAPK 억제제 IV는 고도로 특이적인 ATP-경쟁적 p38α입니다. 0.13 및 0.55의 IC50을 갖는 MAPK 억제제 μ p38α의 경우 M; 및 p38β MAPK.
- GC18612 MMP-9/MMP-13 Inhibitor I MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).
- GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB
- GC52334 ENPP1 Inhibitor 4e An ENPP1 inhibitor
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GC43894
IKK2 Inhibitor VI
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.
- GC43239 Chk2 Inhibitor Chk2 억제제(화합물 1)는 Chk2 및 Chk1에 대한 IC50이 각각 13.5nM 및 220.4nM인 체크포인트 키나제 2(Chk2)의 강력하고 선택적인 억제제입니다. Chk2 억제제는 강한 ATM(ataxia telangiectasia mutated) 의존성 Chk2 매개 방사선 보호 효과를 유발할 수 있습니다.
- GC52384 NFAT Inhibitor (cell-permeable) (trifluoroacetate salt) A cell-permeable form of NFAT inhibitor
- GC44237 MMP-9 Inhibitor I MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).
- GC52154 Inflammasome Inhibitor 4b
- GC45793 IM-93 IM-93은 세포 사멸 억제에 대해 0.45μM의 IC50으로 ferroptosis와 NETosis를 억제합니다.
- GC40922 SRS11-92 Ferrostatin-1(Fer-1) 유사체인 SRS11-92는 강력한 ferroptosis 억제제입니다.
- GC52516 Erbstatin A tyrosine kinase inhibitor
- GC49903 MRT67307 (hydrochloride) A kinase inhibitor
- GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11
- GC49685 Trifluoroacetyl Tripeptide-2 (acetate) A peptide inhibitor of pancreatic and neutrophil elastases
- GC49266 Compstatin (trifluoroacetate salt) A peptide inhibitor of complement activation
- GC49265 PKI (14-22) amide (myristoylated) (trifluoroacetate salt) A PKA inhibitor
- GC48495 BMS-P5 BMS-P5는 특이적 경구 활성 펩티딜아르기닌 데이미나제 4(PAD4) 억제제입니다. BMS-P5는 동계 마우스 모델에서 MM 유도 NET 형성을 차단하고 MM의 진행을 지연시킵니다.
- GC48447 TAS 205 An inhibitor of H-PGDS
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC47533 L-778,123 A dual inhibitor of FTase and GGTase I
- GC47400 GGTI 2133 (trifluoroacetate salt) A geranylgeranyl transferase I inhibitor
- GC47387 G6PDi-1 G6PDi-1은 IC50이 0.07μM인 가역적이고 비경쟁적인 포도당-6-인산 탈수소효소(G6PD) 억제제입니다.
- GC47129 CU-76 A cGAS inhibitor
- GC47128 CU-32 A cGAS inhibitor
- GC46984 C-171 C-171은 인터페론 유전자 자극제(STING)의 억제제입니다.
- GC46983 C-170 C-170(C-170)은 강력하고 공유적인 STING 억제제입니다.
- GC46630 4-CPPC A MIF-2 inhibitor
-
GC18572
Concanavalin A
콘카나마이신 A는 Streptomyces diastatochromogenes에서 분리된 매크로라이드 항생물질인 콘카나마이신 가족에 속하며, 고도로 활성화되고 선택적으로 세포질 프로톤-ATPase (v-[H+]ATPase)를 억제하는 항생제입니다.
- GC46154 Hexylglutathione An mtMGST1 inhibitor
- GC45995 DO264 An ABHD12 inhibitor
- GC45960 9c(i472) 9c(i472)는 IC50 값이 0.19 μ인 15-LOX-1(15-리폭시게나제-1)의 강력한 억제제입니다.
- GC45951 BLX3887 A 15-LO-1 inhibitor
- GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2
- GC45057 TIQ-A TIQ-A는 TNKS2에 대해 IC50이 24nM인 강력한 TNKS(폴리-ART, PARP) 억제제입니다.
- GC45012 Tenofovir diphosphate (sodium salt) Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM).
- GC44948 StA-IFN-1 StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1, which specifically inhibits the IKKβ component of the IFN induction pathway.
- GC44919 SP 600125, negative control SP 600125 is a selective, cell-permeable, reversible inhibitor of JNK isoforms 1-3 with Ki values of 0.19 μM.
- GC44794 Pyrrophenone 피로페논은 IC50 값이 4.2nM인 강력하고 특이적인 세포질 포스포리파제 A2α(cPLA2α) 억제제입니다.
- GC44505 Oleyl Anilide AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.
- GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.
- GC44212 MK-886 (sodium salt) Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).
- GC44052 Leukotriene B4 dimethyl amide LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL.
- GC44014 KT109 KT109는 IC50이 42nM인 강력한 디아실글리세롤 리파제-β(DAGLβ)의 동형 선택적 억제제입니다.
- GC43883 Hymeglusin Hymeglusin은 곰팡이 β-lactone계 항생제로서 HMG-CoA synthase inhibitor이다(IC50=0.12μM).
- GC43773 Glyburide (potassium salt) Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).
- GC43492 DL-Propargyl Glycine (hydrochloride) Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.
- GC43453 Diflapolin 디플라폴린은 현저한 항염증 효능과 높은 표적 선택성을 가진 고활성 이중 5-리폭시게나제-활성화 단백질(FLAP)/용해성 에폭시드 가수분해효소(sEH) 억제제입니다.
- GC43176 CAY10575 CAY10575(화합물 8)는 IC50이 0.075 μ인 IKK2 억제제입니다.
- GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
- GC42897 BAY 61-3606 (hydrochloride) BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM).
- GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).
- GC42338 4-Aminobenzoic Acid hydrazide 4-Aminobenzoic Acid hydrazide는 IC50이 0.3 μ인 비가역적 MPO myeloperoxidase 억제제입니다.
-
GC41638
TSI-01
혈소판 활성화 인자(PAF)는 외부 자극에 대한 반응으로 라이소-PAF 아세틸전이효소(lyso-PAFAT)에 의해 신속하게 합성되는 염증 유도 인지질 매개체입니다.
- GC19001 Tetromycin B Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively.
- GC18877 CAY10606 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations.
- GC18782 CAY10657 The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules.
- GC18517 Diapocynin Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities.