Chitoheptaose |
Catalog No.GB57664
One-Click Copy Product Info
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Chitoheptaose is a chitosan oligosaccharide monomer with a degree of polymerization of 7.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68232-35-9
Sample solution is provided at 25 µL, 10mM.
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Chitoheptaose is a chitosan oligosaccharide monomer with a degree of polymerization of 7. Chitoheptaose exhibits anti-inflammatory and antioxidant activities[1].
In vitro, Chitoheptaose (0-400μM; 24h) exhibited no significant cytotoxicity in RAW 264.7 macrophages[1]. Chitoheptaose (200μM; 30-48h) significantly inhibited LPS-induced NO production, reduced IL-6 and TNF-α secretion, and suppressed the overexpression of p-IκBα in RAW 264.7 macrophages[1]. Chitoheptaose (200-800μg/mL; 24h) showed no significant cytotoxicity in HaCaT human keratinocytes, but exhibited certain toxicity at 1000μg/mL[2].
References:
[1] Zhao M, Pang S, Gao Y, Li T, Jiang H. Effect of Chitooligosaccharides on TLR2/NF-κB Signaling in LPS-Stimulated RAW 264.7 Macrophages. Molecules. 2025;30(10):2226.
[2] Zhang J, Wang W, Mao X. Chitopentaose protects HaCaT cells against H2O2-induced oxidative damage through modulating MAPKs and Nrf2/ARE signaling pathways. J Funct Foods. 2020;72:104086.
| Cell experiment [1]: | |
Cell lines | RAW 264.7 macrophages |
Preparation Method | RAW 264.7 macrophages were plated in 96-well plates at a density of 5×105cells per well and incubated for 24h. Then, 100μL of Chitoheptaose at varying concentrations (0-400μM) was added to the cells and incubated for an additional 24h. |
Reaction Conditions | 0-400μM; 24h |
Applications | Chitoheptaose did not inhibit cell viability at concentrations up to 400μM. |
References: | |
| Cas No. | 68232-35-9 | SDF | |
| Formula | C42H79N7O29 | M.Wt | 1146.11 |
| Solubility | Storage | 2-8°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 872.5 μL | 4.3626 mL | 8.7252 mL |
| 5 mM | 174.5 μL | 872.5 μL | 1.745 mL |
| 10 mM | 87.3 μL | 436.3 μL | 872.5 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)