Cyclosomatostatin |
Catalog No.GC15495 |
사이클로소마토스타틴은 강력한 소마토스타틴(SST) 수용체 길항제입니다. 사이클로소마토스타틴은 소마토스타틴 수용체 유형 1(SSTR1) 신호 전달을 억제하고 세포 증식, ALDH+ 세포 집단 크기 및 결장직장암(CRC) 세포에서 구체 형성을 감소시킬 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 84211-54-1
Sample solution is provided at 25 µL, 10mM.
IC50: N/A
Cyclosomatostatin is a non-selective somatostatin receptor antagonist.
Somatostatin is a regulatory hormone or tissue factor playing an inhibitory role in the normal regulation of several organ systems including hypothalamus and pituitary gland, central nervous system, gastrointestinal tract as well as pancreas.
In vitro: Although cyclosomatostatin could fully block the effect of somatostatin, it only partially reversed the inhibitory effect of cortistatin, a new anti-inflammatory peptide. This observation was further supported by the fact that cyclosomatostatin reversed the antiinfl ammatory effect of somatostatin and octreotide in vitro completely, while only partially reversing the effect of cortistatin [1].
In vivo: The effect of cortistatin was found to be dose dependent, with dose as low as 0.5 nmol (50 μg/kg) being partially protective. In contrast, cyclosomatostatin, somatostatin as well as octreotide were not protective [1].
Clinical trial: As the precursor of cyclosomatostatin, somatostatin has already been introduced in the clinical practice in some macrophage populations. Somatostatin shows protective effect in certain inflammatory disorders including pancreatitis and liver injury. However, somatostatin is not protective in lethal septic shock [1].
Reference:
[1] Gonzalez-Rey E,Chorny A,Robledo G,Delgado M. Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. J Exp Med.2006 Mar 20;203(3):563-71.
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