Cypermethrin |
Catalog No.GC47158
One-Click Copy Product Info
|
A type II pyrethroid insecticide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 52315-07-8
Sample solution is provided at 25 µL, 10mM.
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Cypermethrin is a type II pyrethroid insecticide.1,2,3,4 It prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system, and point mutations in sodium channels induce cypermethrin-resistance in house flies, cockroaches, and mosquitos.3 Cypermethrin (1-1.5 mg) reduces survival of ticks (H. anatolicum) in vitro in a concentration-dependent manner.2 Topical administration of cypermethrin reduces the number of ticks on infested cattle. Cypermethrin (5 and 10 ppm) reduces survival of lice (D. ovis) in sheep fleece and prevents re-infestation in contact-challenged sheep for 7 and 19 weeks, respectively.1 It induces developmental neurotoxicities in zebrafish, increasing mortality and edema and inducing body-axis curvature when used at concentrations ranging from 50 to 200 μg/L.5 Cypermethrin (15 mg/kg twice weekly for 24 weeks) also induces Parkinson's disease-like neurodegeneration in rats, decreasing locomotor activity, dopamine production, and the number of tyrosine hydroxylase positive (TH+) neurons in the substantia nigra.4
1.Hall, C.A.The efficiency of cypermethrin (NRDC 149) for the treatment and eradication of the sheep louse Damalinia ovisAust. Vet. J.54(10)471-472(1978) 2.Sajid, M.S., Iqbal, Z., Khan, M.N., et al.In vitro and in vivo efficacies of ivermectin and cypermethrin against the cattle tick Hyalomma anatolicum anatolicum (Acari: Ixodidae)Parasitol Res.105(4)1133-1138(2009) 3.Hu, Z., Du, Y., and Dong, K.A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroidsInsect Biochem. Mol. Biol.41(1)9-13(2011) 4.Singh, A.K., Tiwari, M.N., Prakash, O., et al.A current review of cypermethrin-induced neurotoxicity and nigrostriatal dopaminergic neurodegenerationCurr. Neuropharmacol.10(1)64-71(2012) 5.DeMicco, A., Cooper, K.R., Richardson, J.R., et al.Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryosToxicol. Sci.113(1)177-186(2010)
| Cas No. | 52315-07-8 | SDF | |
| Canonical SMILES | O=C(C1C(C)(C)C1/C=C(Cl)\Cl)OC(C#N)C2=CC(OC3=CC=CC=C3)=CC=C2 | ||
| Formula | C22H19Cl2NO3 | M.Wt | 416.3 |
| Solubility | Chloroform: Slightly Soluble,Methanol: Slightly Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4021 mL | 12.0106 mL | 24.0211 mL |
| 5 mM | 480.4 μL | 2.4021 mL | 4.8042 mL |
| 10 mM | 240.2 μL | 1.2011 mL | 2.4021 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)