Dinactin |
| Catalog No.GC13564 |
암 세포에서 Wnt/β-카테닌 신호 전달 경로를 표적으로 하는 효과적인 소분자로서 Streptomyces 종에 의해 생성된 항생제 이온 전달 물질인 Dinactin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20261-85-2
Sample solution is provided at 25 µL, 10mM.
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Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K+, NH4+, and Rb+.1 It is commonly used to study membrane properties.[1],[2] Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces.[3] Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.[4]
Reference:
[1]. Laprade, R., Grenier, F., Pagé-Dansereau, M., et al. Carrier-mediated ion transport in lipid bilayer membranes. Can. J. Biochem. Cell Biol. 62(8), 738-751 (1984).
[2]. Lapointe, J.-Y., and Laprade, R. Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. Biophys. J. 39(2), 141-150 (1982).
[3]. Silva, L.J., Crevelin , E.J., Souza, W.R., et al. Streptomyces araujoniae Produces a Multiantibiotic Complex with Ionophoric Properties to Control Botrytis cinerea. Phytopathology 104(12), 1298-1305 (2014).
[4]. Umland, S.P., Shah, H., Jakway, J.P., et al. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Am. J. Respir. Cell Mol. Biol. 20(3), 481-492 (1999).
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