DL-erythro-PDMP (hydrochloride)

DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.^1,2 It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 µM.² Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 µM.³ It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 µM but is cytotoxic at concentrations higher than 50 µM.⁴ [Matreya, LLC. Catalog No. 1755]

1.Vunnam, R.R., and Radin, N.S.Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brainChem. Phys. Lipids26(3)265-278(1980) 2.Abe, A., Radin, N.S., and Shayman, J.A.Induction of glucosylceramide synthase by synthase inhibitors and ceramideBiochim. Biophys. Acta.1299(3)333-341(1996) 3.Inokuchi, J.i., and Radin, N.S.Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetaseJ. Lipid Res.28(5)565-571(1987) 4.Uemura, K., Sugiyama, E., Tamai, C., et al.Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblastsJ. Biochem.108(4)525-530(1990)