DMX-5804 |
| Catalog No.GC65298 |
DMX-5804는 강력한 경구 활성 및 선택적 MAP4K4 억제제로, IC50은 3nM, pIC50은 인간 MAP4K4에 대해 8.55, MINK1/MAP4K6(pIC50, 8.18) 및 TNIK/MAP4K7(pIC50)에 대해 덜 강력합니다. .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2306178-56-1
Sample solution is provided at 25 µL, 10mM.
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DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].
DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC50, 6.50), GLK/MAP4K3 (pIC50, 4.95), KHS/MAP4K5 (pIC50, 6.36), ABL1 (pIC50, 5.80), Aurora B (pIC50, 5.49), FLT3 (pIC50, 5.31), GSK3β (pIC50, 4.66), MLK1/MAP3K9 (pIC50, 7.19), MLK3/MAP3K11 (pIC50, 6.99), NUAK (pIC50, 6.88) and VEGFR (pIC50, 5.72)[1].
[1]. Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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