DYRKs-IN-1 hydrochloride |
| Catalog No.GC62947 |
DYRKs-IN-1 염산염은 DYRK1A 및 DYRK1B에 대해 각각 IC50이 5nM 및 8nM인 강력한 DYRK(이중 특이성 티로신-인산화 조절 키나제) 억제제입니다. DYRKs-IN-1 염산염은 항종양 활성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1386980-55-7
Sample solution is provided at 25 µL, 10mM.
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DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2].
DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1]. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor[2].
[1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.
[2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.
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