E3 ligase Ligand 9 |
| Catalog No.GC34566 |
E3 리가아제 리간드 9는 E3 유비퀴틴 리가아제에 대한 리간드입니다. E3 리가제 리간드 9는 링커에 의해 단백질 리간드에 연결되어 PROTAC 또는 SNIPER를 형성할 수 있습니다. PROTAC은 암 촉진 단백질의 유비퀴틴화 매개 분해를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093388-45-3
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1]. E3 ligase[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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